Epidemiological study of new oral anticoagulants
نویسندگان
چکیده
منابع مشابه
epidemiological study of oral and pharyngeal cancers in kermanshah province from march 1993 to march 2006
چکیده ندارد.
15 صفحه اولThe new oral anticoagulants.
Although their first application in clinical practice occurred in the 1940s, vitamin K antagonists remain the only form of oral anticoagulant medication approved for long-term use. Although the available vitamin K antagonists are highly effective for the prevention and/or treatment of most thrombotic disease, the significant interpatient and intrapatient variability in dose-response, the narrow...
متن کاملReversal of new oral anticoagulants.
Although the options for therapeutic modalities such as chemotherapy and antibiotics have flourished, anticoagulant management has remained stagnant since the first agents were developed during World War II. Traditional anticoagulants widely used to treat thromboembolic disease include heparin-based drugs and warfarin. These drugs are cumbersome to administer. They have a narrow therapeutic win...
متن کاملNew oral anticoagulants in development.
Although currently available anticoagulants are effective for the prevention and treatment of thromboembolic disorders, they have several drawbacks. Low-molecular-weight heparins and fondaparinux produce a predictable level of anticoagulation that obviates the need for coagulation monitoring, but they must be given parenterally, which renders them inconvenient for long-term use. Vitamin K antag...
متن کاملNew issues in oral anticoagulants.
Polymorphisms in CYP2C9, a critical cytochrome P-450 enzyme in the metabolism of warfarin, alters its clearance and affects dosing. CYP*1 has higher activity than either the *2 or *3 variants, and patients with the *2 or *3 variants require a lower dose. VKORC1 is the enzyme inhibited by warfarin, and its levels are affected by several polymorphisms that can be divided into high or low level ha...
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ژورنال
عنوان ژورنال: Klinická farmakologie a farmacie
سال: 2018
ISSN: 1212-7973,1803-5353
DOI: 10.36290/far.2018.008